DEVELOPMENT OF ACECLOFENAG OSMOTIC PUMP TABLET FOR CONTROLLED DRUG DELIVERY

摘要

Based on monolithic osmotic pump, aceclofenac tablet for controlled drug release system was developed to deliver the drug in a zero order kinetic mode. These osmotic tablets containing 100 mg Aceclofenac were prepared and coated with microporous membrane. The Osmotic Controlled Tablets (OCT) was prepared by using variables like osmogen and osmopolymer. All the tablets were examined and evaluated for physical parameters as well as the in vitro drug release characteristics, studied on USP dissolution apparatus II in 0.1 N HCI and phosphate buffer pH 6.8. The drug releases from OCT were found to be dependent on types of osmogens and osmopolymer. All the formulations showed prolonged and controlled aceclofenac release. Sodium chloride based formulation exhibit slightly higher rate and extent of drug release than potassium chloride. Pectin and sodium chloride based tablets offered high push significantly due to higher osmotic pressure.