Discovery of Carbono(di)thioates as Indoleamine 2,3-Dioxygenase 1 Inhibitors

Miyuki  Kumazawa; Manabu  Tejima; Miwa  Fukuda; Shota  Takeda; Kenji  Suzuki; Yukiko  Mizumoto; Kakeru  Sato; Minoru  Waki; Hiroyuki  Miyachi; Akira  Asai; Osamu  Takikawa; Tomoko  Hashimoto; Osamu  Ohno; Kenji  Matsuno

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Discovery of Carbono(di)thioates as Indoleamine 2,3-Dioxygenase 1 Inhibitors

机译：将Carbono（DI）硫酸酯的发现为吲哚胺2,3-二氧化酶1抑制剂

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《ACS medicinal chemistry letters》 |2021年第2期|共6页
作者
Miyuki Kumazawa; Manabu Tejima; Miwa Fukuda; Shota Takeda; Kenji Suzuki; Yukiko Mizumoto; Kakeru Sato; Minoru Waki; Hiroyuki Miyachi; Akira Asai; Osamu Takikawa; Tomoko Hashimoto; Osamu Ohno; Kenji Matsuno;
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作者单位

Laboratory of Medicinal Chemistry Department of Chemistry and Life Science School of Advanced Engineering Kogakuin University;

Laboratory of Medicinal Chemistry Department of Chemistry and Life Science School of Advanced Engineering Kogakuin University;

Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama University;

Laboratory of Medicinal Chemistry Department of Chemistry and Life Science School of Advanced Engineering Kogakuin University;

Laboratory of Medicinal Chemistry Department of Chemistry and Life Science School of Advanced Engineering Kogakuin University;

Laboratory of Medicinal Chemistry Department of Chemistry and Life Science School of Advanced Engineering Kogakuin University;

Laboratory of Medicinal Chemistry Department of Chemistry and Life Science School of Advanced Engineering Kogakuin University;

Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama University;

Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama University;

Graduate School of Pharmaceutical Sciences University of Shizuoka;

National Institute for Longevity Sciences National Center for Geriatrics and Gerontology;

Laboratory of Medicinal Chemistry Department of Chemistry and Life Science School of Advanced Engineering Kogakuin University;

Laboratory of Medicinal Chemistry Department of Chemistry and Life Science School of Advanced Engineering Kogakuin University;

Laboratory of Medicinal Chemistry Department of Chemistry and Life Science School of Advanced Engineering Kogakuin University;

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原文格式 PDF
正文语种 eng
中图分类药学;化学;
关键词
indoleamine 2; 3-dioxygenase 1; inhibitor; kynurenine; carbonothioate; carbonodithioate; Soret band;

机译：indolemine 2;3-二恶英酶1;抑制剂;kynurenine;carbanothioate;碳二硫酸盐;soret带;

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专利

1. Discovery and characterization of natural products as novel indoleamine 2,3-dioxygenase 1 inhibitors through high-throughput screening [J] . Wei Guo, Sheng Yao, Pu Sun, 中国药理学报：英文版 . 2020,第003期
2. Discovery of the first potent proteolysis targeting chimera(PROTAC) degrader of indoleamine 2,3-dioxygenase 1 [J] . Mingxing Hu, Weilin Zhou, Yijie Wang, 药学学报：英文版 . 2020,第010期
3. Discovery of the first potent proteolysis targeting chimera (PROTAC) degrader of indoleamine 2,3-dioxygenase 1 [J] . Mingxing Hu, Wei Wang, Yongmei Xie, 药学学报（英文版） . 2020,第010期
4. Feiji Recipe inhibits the growth of lung cancer by modulating T-cell immunity through indoleamine-2,3-dioxygenase pathway in an orthotopic implantation model [J] . Bin Luo1, Zu-jun Que2, Zhi-yi Zhou1, 结合医学学报：英文版 . 2018,第004期
5. Diaryl hydroxylamines as pan or dual inhibitors of indoleamine 2,3-dioxygenase-1, indoleamine 2,3-dioxygenase-2 and tryptophan dioxygenase [J] . Winters Maria, DuHadaway James B., Pham Khoa N., European Journal of Medicinal Chemistry: Chimie Therapeutique . 2019,第期

机译：indryl羟胺作为吲哚胺的锅或双抑制剂2,3-二氧基酶-1，indoleamine 2,3-二氧化酶-2和色氨酸二恶英酶
6. Forty‐three key gene expressions involved in the effect of indoleamine 2,3‐dioxygenase 1 expression on cancer prognosis may be a potential indoleamine 2,3‐dioxygenase 1 inhibitor biomarker [J] . Weirui Li, Leilei Guo, Zikang Xing, Clinical and Translational Medicine . 2021,第2期

机译：参与吲哚胺2,3-二恶英酶1对癌症预后的表达的43个关键基因表达可能是含吲哚胺2,3-二氧化根酶1抑制剂生物标志物
7. AncPhore: A versatile tool for anchor pharmacophore steered drug discovery with applications in discovery of new inhibitors targeting metallo-β-lactamases and indoleamine/tryptophan 2,3-dioxygenases [J] . Qingqing Dai, Yuhang Yan, Xiangli Ning, Acta Pharmaceutica Sinica B . 2021,第7期

机译：ANCPHORE：用于锚定药物的多功能工具，用于发现靶向金属-β-内酰胺酶的新抑制剂和吲哚胺/色氨酸2,3-二氧化酶的新抑制剂中的应用
8. Clinical aspects of indoleamine 2,3-dioxygenase(IDO)-initiated tryptophan metabolism: IDO is atarget of drug discovery for various diseases [C] . O. Takikaw International Study Group for Tryptophan Research . 2007

机译：吲哚胺2,3-二恶英酶（IDO） - intinited色氨酸代谢的临床方面：IDO是各种疾病的药物发现的悖论
9. Design and Synthesis of Hydroxylamine Derivatives as Indoleamine-2,3-Dioxygenase Inhibitors. [D] . Winters, Maria. 2014

机译：吲哚胺-2,3-二加氧酶抑制剂羟胺衍生物的设计与合成。
10. Discovery of Novel Inhibitors of Indoleamine 2,3-Dioxygenase 1 Through Structure-Based Virtual Screening [O] . Guoqing Zhang, Jing Xing, Yulan Wang, 2018

机译：通过基于结构的虚拟筛选发现吲哚胺2,3-双加氧酶1的新型抑制剂。
11. Diaryl hydroxylamines as pan or dual inhibitors of indoleamine 2,3-dioxygenase-1, indoleamine 2,3-dioxygenase-2 and tryptophan dioxygenase [O] . Maria Winters, James B. DuHadaway, Khoa N. Pham, 2019

机译：indryl羟胺作为吲哚胺的锅或双抑制剂2,3-二氧基酶-1，indoleamine 2,3-二氧化酶-2和色氨酸二恶英酶
12. Regulation of T Cell-Mediated Immunity by D Isomers of Inhibitors of Indoleamine-2,3-Dioxygenase. [R] . Munn, D., Mellor, A. 2004

机译：通过吲哚胺-2,3-双加氧酶抑制剂的异构体调节T细胞介导的免疫。

Discovery of Carbono(di)thioates as Indoleamine 2,3-Dioxygenase 1 Inhibitors

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