Novel Benzimidazole Derivatives as Transient Receptor Potential Channel 6 (TRPC6) Inhibitors

Ram W.  Sabnis

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Novel Benzimidazole Derivatives as Transient Receptor Potential Channel 6 (TRPC6) Inhibitors

机译：新型苯并咪唑衍生物作为瞬态受体电位通道6（TRPC6）抑制剂

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来源
《ACS medicinal chemistry letters》 |2021年第3期|共2页
作者
Ram W. Sabnis;
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Smith Gambrell &

Russell LLP;

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正文语种 eng
中图分类药学;化学;
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1. Hewei Jiangni granule alleviates visceral hypersensitivity in a rat model of non-erosive reflux disease via transient receptor potential channel signaling [J] . Jiali Liu, Fushun Kou, Xiang Tan, 中医科学杂志(英文) . 2020,第002期
2. Canonical transient receptor potential channel (TRPC)3 and TRPC6 associate with large-conductance Ca2+-activated K+ (BKCa) channels: role in BKCa trafficking to the surface of cultured podocytes. [J] . Kim EY, Alvarez-Baron CP, Dryer SE Molecular pharmacology. . 2009,第3期

机译：典型的瞬态受体电位通道（TRPC）3和TRPC6与大电导Ca2 +激活的K +（BKCa）通道相关：在BKCa转运到培养足细胞表面中的作用。
3. A polycystin-type transient receptor potential (Trp) channel that is activated by ATP A polycystin-type transient receptor potential (Trp) channel that is activated by ATP A polycystin-type transient receptor potential (Trp) channel that is activated by ATP [J] . Robert R. Kay, David Traynor Biology Open . 2017,第2期

机译：由ATP激活的多囊藻毒素型瞬时受体电位（Trp）通道由ATP激活的多囊藻毒素型瞬时受体电位（Trp）通道由ATP激活的多囊藻毒素类型瞬态受体电位（Trp）通道
4. Discovery of a bicyclo[4.3.0]nonane derivative DS88790512 as a potent, selective, and orally bioavailable blocker of transient receptor potential canonical 6 (TRPC6) [J] . Motoyama Keisuke, Nagata Tsutomu, Kobayashi Jun, Bioorganic and Medicinal Chemistry Letters . 2018,第12期

机译：发现双环[4.3.0]壬烷衍生物DS88790512作为瞬态受体潜在规范6的有效，选择性和口服生物可利用的阻滞剂6（TRPC6）
5. SYNTHESIS AND ANTIFUNGAL ACTIVITY EVALUATION OF NEW BENZIMIDAZOLE-TRIAZOLE DERIVATIVES AS POTENTIAL ERGESTEROL BIOSYNTHESIS INHIBITORS USING LC-MS/MS [C] . Nafiz Oncu Can, Ulviye Acar Cevik, Begum Nurpelin Saglik, International Mass Spectrometry Conference . 2018

机译：新型苯并咪唑 - 三唑衍生物作为使用LC-MS / MS的潜在伊代甲生物合成抑制剂的合成与抗真菌活性评价
6. M1 muscarinic acetylcholine receptor regulation of endogenous transient receptor potential-canonical, subtype 6 (TRPC6) channels. [D] . Kim, Ju Young. 2005

机译：M1毒蕈碱型乙酰胆碱受体调节内源性瞬时受体电位-典型亚型6（TRPC6）通道。
7. Canonical Transient Receptor Potential Channel (TRPC) 3 and TRPC6 Associate with Large-Conductance Ca2+-Activated K+ (BKCa) Channels: Role in BKCa Trafficking to the Surface of Cultured Podocytes [O] . Eun Young Kim, Claudia P. Alvarez-Baron, Stuart E. Dryer -1

机译：典型的瞬态受体电位通道（TRPC）3和TRPC6 与大电导Ca2 +激活的K +相关（BKCa）渠道：在BKCa投放到地面的角色培养足细胞
8. Canonical Transient Receptor Potential Channel (TRPC) 3 and TRPC6 Associate with Large-Conductance Ca2+-Activated K+ (BKCa) Channels: Role in BKCa Trafficking to the Surface of Cultured Podocytes [O] . Kim, Eun Young, Alvarez-Baron, Claudia P., Dryer, Stuart E. 2008

机译：典型的瞬态受体电位通道（TRPC）3和TRPC6 与大电导Ca2 +激活的K +相关（BKCa）渠道：在BKCa投放到地面的角色培养足细胞
9. Brain Damage from Soman-Induced Seizures Is Greatly Exacerbated by Dimethyl sulfoxide (DMSO): Modest Neuroprotection by 2-Aminoethyl diphenylborinate (2- APB), a Transient Receptor Potential Channel Inhibitor and Inositol 1,4,5-triphosphate Receptor Antagonist [R] . Ballough, G. P., Kan, R. K., Nicholson, J. D., 2008

机译：二甲基亚砜（DmsO）大大加剧梭曼诱发癫痫发作引起的脑损伤：2-氨基乙基二苯基硼酸盐（2- apB），一种瞬时受体电位通道抑制剂和肌醇1,4,5-三磷酸受体拮抗剂的适度神经保护作用

Novel Benzimidazole Derivatives as Transient Receptor Potential Channel 6 (TRPC6) Inhibitors

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