Formation constants of polynuclear aromatic compounds and beta-cyclodextrin inclusion complexes in beta-cyclodextrin modified mobile phase high performance liquid chromatography system

摘要

The effects of molecular size and shape upon the formation of inclusion complexes of beta-cyclodextrin (beta-CD) and polynuclear aromatic compounds in beta-CD modified mobile phase high performance liquid chromatography (HPLC) system were studied. A correlation was established between the molecular size and shape of the probe compounds and the formation constants of the inclusion complexes. The formation constants were then used to support the elucidation of inclusion complexes formation based on the structural properties.