New Paradigms for Anticoagulation in Pregnant Women With Inherited Thrombophilia

摘要

DA The term thrombophilia is used to describe conditions associated with an increased predisposition to the development of venous thromboembolism (VTE). Acquired forms of thrombophilia include antiphospholipid syndrome, paroxysmal nocturnal hemoglobinuria, and myelopro-liferative disease, whereas inherited forms include factor V Leiden (FVL) variant (G1691A), prothrombin gene (PGA) variant (G20210A), protein C deficiency, protein S deficiency, and antithrombin (AT) deficiency. Inherited thrombophilia is more common among people with European ancestry than among other ethnic groups, with a prevalence of up to 15%.