SIMULTANEOUS DETERMINATION OF GUAIFENESIN AND THEOPHYLLINE BY CHEMOMETRICS METHODS

摘要

In this study, simultaneous spectrophotometry determination of guaifenesin and theophylline in pharmaceuticals by chemometric approaches has been reported. Spectra of mixtures of these drugs were recorded and corresponding first derivatives were calculated. Partial least squares regression (PLS) alone and ant colony optimization (ACO) coupled with PLS were used in analysis of the data. Ant colony system (ACS) as an efficient ACO algorithm was used. In addition, ACS was combined to genetic algorithm (GA) to produce better results. The analytical performances of these chemometric methods were characterized by relative prediction errors. These methods were successfully applied to pharmaceutical formulation.