Analytical applications of ion-associate complexes for the micro-determination of loratadine hydrochloride in pharmaceutical formulations and urine samples

摘要

Ion - associate complexes of Loratadine hydrochloride with [manganese (II), cobalt(II) thiocyanate], potassium ferricyanide and ammonium reineckate were precipitated and the excess unreacted metal complex was determined. A new method was given for the determination of Loratadine drug in pure solutions, in pharmaceutical formulations and urine samples using atomic emission and atomic absorption spectrometry. The drug can be determined by the affort method in the range 0.76 - 68.92 μg mL~(-1).