Tackling quantitative polymorphic analysis through fixed-dose combination tablets production. Pyrazinamide polymorphic assessment

Antonio Marina; Raffaghelli Mariano; Maggio Ruben M.

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Tackling quantitative polymorphic analysis through fixed-dose combination tablets production. Pyrazinamide polymorphic assessment

机译：通过固定剂组合片生产来解决定量多态性分析。吡嗪酰胺多态评估

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摘要

Pyrazinamide (PZA), Rifampicin (RIF), Isoniazid (ISH) and Ethambutol (ETB) form the core for the treatment of Tuberculosis, today a devastating disease in low-income populations around the world. These drugs are usually administrated by fixed-dose combination (FDC) products, to favour the patient compliance and prevent bacterial resistance.

机译：吡嗪酰胺（PZA）、利福平（RIF）、异烟肼（ISH）和乙胺丁醇（ETB）构成了结核病治疗的核心。如今，结核病是全世界低收入人群的一种毁灭性疾病。这些药物通常通过固定剂量组合（FDC）产品给药，以促进患者的依从性并防止细菌耐药性。

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来源
《Journal of Pharmaceutical and Biomedical Analysis: An International Journal on All Drug-Related Topics in Pharmaceutical, Biomedical and Clinical Analysis》 |2021年第1期|共9页
作者
Antonio Marina; Raffaghelli Mariano; Maggio Ruben M.;
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作者单位

Univ Nacl Rosario Area Anal Medicamentos Fac Ciencias Bioquim &

Farmaceut Suipacha 531 S2002LRK;

Area Desarrollo Lab Ind Farmaceut SE French 4950 S3006ETP Santa Fe Argentina;

Univ Nacl Rosario Area Anal Medicamentos Fac Ciencias Bioquim &

Farmaceut Suipacha 531 S2002LRK;

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原文格式 PDF
正文语种 eng
中图分类药学;
关键词
Pyrazinamide (PZA); Polymorphism; Fixed-dose combination (FDC); Near infrared spectroscopy (NIR); Partial least squares (PLS); Process analytical technology (PAT);

机译：吡嗪酰胺（PZA）;多态性;固定剂量组合（FDC）;近红外光谱（NIR）;部分最小二乘（PLS）;过程分析技术（PAT）;

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2. Assessment of Genetic Variation Within Indian Mustard(Brassica juncea) Germplasm Using Random Amplified Polymorphic DNA Markers [J] . Muhammad Ayub Khan, Malik Ashiq Rabbani, Muharnmad Munir, 植物学报（英文版） . 2008,第004期
3. Optimization of a reversed-phase-high-performance thin-layer chromatography method for the separation of isoniazid, ethambutol, rifampicin and pyrazinamide in fixed-dose combination antituberculosis tablets [J] . Shewiyo D.H., Kaale E., Risha P.G., Journal of chromatography, A: Including electrophoresis and other separation methods . 2012,第Null期

机译：反相高效薄层色谱法用于固定剂量联合抗结核药中异烟肼，乙胺丁醇，利福平和吡嗪酰胺的分离
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Tackling quantitative polymorphic analysis through fixed-dose combination tablets production. Pyrazinamide polymorphic assessment

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