Host-guest interaction of trimethoprim drug with cyclodextrins in aqueous solutions: Calorimetric, spectroscopic, volumetric and theoretical approach

摘要

Owing to the internal cavity of cyclodextrins, they are very notable to form the inclusion complexeswith various drugs. In present work, the binding of trimethoprim (TMP) drug with native alpha-, beta-, and gamma-cyclodextrins (CDs) were systematically examined using the isothermal titration calorimetry (ITC), spectroscopic {UV-visible, nuclear magnetic resonance (NMR)} methods, dynamic light scattering (DLS) and molecular modeling of the complex formed by host (cyclodextrins) and guest (trimethoprim) molecules. The stability of the TMP-CDs inclusion complexes increases in the following order: alpha-CD