Photostability Study of Doxorubicin Aqueous Solution Enhanced by Inclusion Interaction between Doxorubicin and Hydroxypropyl-β-cyclodextrin

摘要

The photodegradation of doxorubicin (Dox) in the presence of hydroxypropyl-β-cyclodextrin (HP-β-CD) was studied; the degradation rate constant in the presence of HP-β-CD estimated by Lineweaver-Burk analysis was approximately three times lower than that of free Dox aqueous solution, which shows that HP-β-CD can enhance the photostability of doxorubicin aqueous solution. The enhancement may be attributed to the inclusion interaction between HP-β-CD and doxorubicin. The characterization of FTIR, DSC, XRD and fluorescence titration indicates that 1∶1 inclusion complex is formed between HP-β-CD and doxorubicin.