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Clear aqueous sulphonamide-trimethoprim solutions - contg. a water-soluble sulphonamide salt, trimethoprim and polyvinyl pyrrolidone of K-value 10-18
Clear aqueous sulphonamide-trimethoprim solutions - contg. a water-soluble sulphonamide salt, trimethoprim and polyvinyl pyrrolidone of K-value 10-18
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机译:清澈的磺酰胺-甲氧苄啶水溶液-续。水溶性磺酰胺盐,甲氧苄啶和聚乙烯吡咯烷酮,K值为10-18
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摘要
New clear, aq. sulphonamide/trimethoprim solns. contain (a) a water-soluble sulphonamide salt, (b) trimethoprim and (c) polyvinyl pyrrolidone with a K-value of 10-18 in water, opt. with the addition of further substances and/or solvents. Sulphonamide/trimethoprim solns. are provided for oral, parenteral or external application. The new solns. avoid the need for solvents with poor pharmaceutical acceptability (e.g., propylene glycol, glycerine formal, dimethylacetamide). The solns. also avoid extreme of pH (which can cause local pain on injection). Typical formulation contains 4 g. sulphamoxole sodium, 0.8 g. trimethoprim, 55 g. polyvinyl pyrrolidone (K-value 12), 0.8 g. sodium sulphite and water for injection to 100 ml.
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