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Electrochemical sensor for phenylpropanolamine based on oligomer derived from 3-hydroxybenzoic acid with dibenzo-18-crown-6

机译:基于苯基丙胺的电化学传感器,基于衍生自3-羟基苯甲酸的低聚物,二苯甲苯-18-Crown-6

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摘要

3-Hydroxybenzoic acid (3HBA) was electrochemically oxidized on a platinum (Pt) and platinum gilded (Pt/Au) electrode surface and further modified with 4-aminodibenzo-18-crown-6 (4ADB18C6). ATR FTIR and FT-Raman spectroscopic techniques were employed to confirm the covalent immobilization of 4ADB18C6 on the 3HBA oxidation product formed on the metallic surface. Conformational changes to the oxyethylene linkage of the crown ether moiety were evident. The affinity between immobilized 4ADB18C6 and phenylpropanolamine was demonstrated by means of electrochemical impedance spectroscopic detection in i) phosphate-buffered saline in the concentration range 9.9 x 10-6-8.00 x 10-5 M (Sr = 0.07-0.11), ii) artificial urine and the pharmaceutical Propalin, which contain 1.0 x 10-5 M and 26.0 x 10-3 M (Sr = 0.11), respectively. The immobilization of the receptor from the crown ether family could be useful for the development of sensor systems that are selective towards amino substances of forensic interest.
机译:3-羟基苯甲酸(3HBA)在铂(Pt)和铂镀金(Pt/Au)电极表面电化学氧化,并进一步用4-氨基二苯并-18-冠-6(4ADB18C6)修饰。采用ATR-FTIR和FT-Raman光谱技术确认4ADB18C6在金属表面形成的3HBA氧化产物上的共价固定。冠醚部分的氧乙烯键的构象变化很明显。在i)浓度范围为9.9 x 10-6-8.00 x 10-5 M(Sr=0.07-0.11)的磷酸盐缓冲盐水中,通过电化学阻抗光谱检测,证明了固定化4ADB18C6和苯丙醇胺之间的亲和力;ii)人工尿液和药物丙烷,分别含有1.0 x 10-5 M和26.0 x 10-3 M(Sr=0.11)。冠醚家族受体的固定化可能有助于开发对法庭感兴趣的氨基物质具有选择性的传感器系统。

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