Application of two-dimensional 1H-31P inverse NMR spectroscopy to the detection of trace amounts of organophosphorus compounds related to the chemical weapons convention.

摘要

Two-dimensional (2D) 1H-31P nuclear magnetic resonance (NMR) techniques were applied to samples containing trace amounts of organophosphorus (OP) compounds related to the Chemical Weapons Convention. Because these techniques allow the recording of 31P-filtered spectra with the sensitivity of proton NMR, the problem of overlapping in 1H NMR spectra was nearly cancelled, while simultaneous 31P and 1H NMR information was obtained quickly. How these experiments are carried out is described. The advantages of 2D techniques are compared with respect to their 1D counterparts, and new developments are proposed for rapid and reliable assignment without the need for reference data of the spiked OP chemicals.