TOP - DOWN PROTEOMICS

摘要

A growing number of labs are using many types of mass spectrometers to directly analyze intact proteins and to improve conversion of MS data into biological knowledge. The timeline for maturation of a new measurement approach is difficult to predict but often accelerates as more laboratories focus on lowering barriers to its progress. Such is the environment of a small but growing number of research teams developing and applying MS for interrogation of intact proteins. This is an extension of tandem MS from small molecules to small peptides (carved from whole proteins by proteolysis), which ushered in the era of proteomics.