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首页> 外文期刊>Brain pathology >Mango leaf extract improves central pathology and cognitive impairment in a type 2 diabetes mouse model
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Mango leaf extract improves central pathology and cognitive impairment in a type 2 diabetes mouse model

机译:芒果叶提取物提高了2型糖尿病小鼠模型中的中央病理学和认知障碍

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摘要

Epidemiological studies reveal that metabolic disorders, and specifically type 2 diabetes (T2D), are relevant risk factors to develop Alzheimer's disease (AD) and vascular dementia (VaD), the most common causes of dementia. AD patients are in a tremendous need of new therapeutic options because of the limited success of available treatments. Natural polyphenols, and concretely Mangifera indica Linn extract (MGF), have been reported to have antiinflammatory, antioxidant and antidiabetic activities. The role of MGF in central complications associated with T2D, after long-term treatment of db/db mice with MGF was analyzed. Metabolic parameters (body weight, glucose and insulin levels) as well as central complications including brain atrophy, inflammatory processes, spontaneous bleeding, tau phosphorylation and cognitive function in db/db mice treated with MGF for 22 weeks were assessed. MGF limits body weight gain in obese db/db mice. Insulin and C-peptide levels, indicative of pancreatic function, were longer maintained in MGF-treated animals. MGF reduced central inflammation by lowering microglia burden, both in the cortex and the hippocampus. Likewise, central spontaneous bleeding was significantly reduced in db/db mice. Cortical and hippocampal atrophy was reduced in db/db mice and tau hyperphosphorylation was lower after MGF treatment, resulting in partial recovery of learning and memory disabilities. Altogether, the data suggested that MGF treatment may provide a useful tool to target different aspects of AD and VaD pathology, and could lead to more effective clinical therapies for the prevention of metabolic related central complications associated with AD and VaD.
机译:流行病学研究表明,代谢紊乱,特异性2型糖尿病(T2D)是开发阿尔茨海默病(AD)和血管痴呆(VAD)的相关风险因素,是痴呆症最常见的原因。由于可用治疗的成功有限,AD患者对新的治疗方案具有巨大需求。据报道,天然多酚和具体的Mangifera indiNa提取物(MGF)具有抗炎,抗氧化和抗糖尿病活性。分析了MGF在与T2D相关的中央并发症中的作用,经过MGF的长期治疗DB / DB小鼠之后的中央并发症。评估代谢参数(体重,葡萄糖和胰岛素水平)以及在用MGF处理22周处理的DB / DB小鼠中,包括脑萎缩,炎症过程,自发性出血,TAU磷酸化和认知功能的中央并发症。 MGF限制肥胖DB / DB小鼠体重增加。胰岛素和C-肽水平,表明胰腺功能较长,较长于MGF处理的动物。通过降低皮质和海马,通过降低小胶质细胞负担来减少中央炎症。同样,在DB / DB小鼠中,中枢自发性出血显着降低。在MGF处理后,DB / DB小鼠的皮质和海马萎缩在DB / DB小鼠中降低,Tau超磷酸化较低,导致学习和记忆障碍的部分恢复。完全,数据表明,MGF治疗可以提供针对广告和VAD病理学的不同方面的有用工具,并且可以导致预防与AD和VAD相关的代谢相关中枢复杂性更有效的临床疗法。

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