A New Catalytic C-C Bond-Forming Hydrogenation: Reductive Coupling of Dienes and Glyoxals under Catalytic Hydrogenation Conditions

摘要

Catalytic reductive C-C bond formation is emerging as an important class of chemical transformation. Recently, progress has been made with regard to the nucleophilic activation of diverse precursors containing π bonds (alkenes, alkynes, enones, and dienes) in regard to catalytic reductive couplings to carbonyl partners. Hydrometallative transformations of this type employ silanes, alanes, and boranes as the terminal reductant, which results in the generation of stoichiometric by-products. while use of elemental hydrogen as the terminal reductant would enable completely atom-economical variants of these catalytic transformations, C-C bond formation has only been observed under hydrogenation conditions in the case of alkenes hydroformylation and Fischer-Tropsch-type processes, that is, catalytic processes involving migratory insertion of carbon monoxide.