Gamma camera calibration and validation for quantitative SPECT imaging with Lu-177

摘要

Over the last years Lu-177 has received considerable attention from the clinical nuclear medicine community thanks, to its wide range of applications in molecular radiotherapy, especially in peptide-receptor radionuclide therapy (PRRT). In addition to short-range beta particles, Lu-177 emits low energy gamma radiation of 113 keV and 208 keV that allows gamma camera quantitative imaging. Despite quantitative cancer imaging in molecular radiotherapy having been proven to be a key instrument for the assessment of therapeutic response, at present no general clinically accepted quantitative imaging protocol exists and absolute quantification studies are usually based on individual initiatives.