Sequential Enzymatic Oxidation of Aminoarenes to Nitroarenes via Hydroxylamines

摘要

Aromatic nitro groups are relatively rare structural elements in natural products, but are found in diverse types of natural products, most of which are endowed with important biological properties. Prominent examples of bacterial nitroaryl metabolites include the potent antibiotic chloramphenicol (1),[1] the antifungal agent pyrrolnitrin (2),[2] and the cytostatic, p-nitrobenzoate-derived polyketide aureothin (3).[3], [4] The nitrophenanthrene derivative aristolochic acid C (4) is the causative agent for Chinese herbs nephropathy[5] and 2-nitrophenol (5) is a well-studied component of the aggregation-attachment pheromone of ticks.