WHEN oxygen delivery falls below a critical threshold, the anaerobic threshold, the amount of oxygen available for consumption is not able to meet the needs of cells. These imbalances result in cellular hypoxia, resulting in the failure of mitochondrial oxida-tive phosphorylation, and as a result energy metabolism becomes wholly dependent on anaerobic glycolysis.1 Anaerobic glycolysis sharply increases the production of cellular lactate, which diffuses into the blood during prolonged cell ischemia.
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