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首页> 外文期刊>American Journal of Physiology >EB 2015 Water and Electrolyte Homeostasis Section Data Diuresis Reviews Endothelium-derived ET-1 and the development of renal injury
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EB 2015 Water and Electrolyte Homeostasis Section Data Diuresis Reviews Endothelium-derived ET-1 and the development of renal injury

机译:EB 2015水和电解质稳态数据Diauresis评论内皮衍生的ET-1和肾损伤的发展

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摘要

The role of the vasoactive peptide endothelin-1 (ET-1) in renal injury is not fully understood. In this review, we examine the genetic models available to understand the autocrine/paracrine mechanisms by which ET-1 leads to renal injury and propose the working hypothesis that endothelium-derived ET-1 induces renal injury by initiating renal tubular apoptosis in a paracrine manner.
机译:血管活性肽内皮素-1(ET-1)在肾损伤中的作用尚不完全理解。 在本文中,我们检查可用于了解ET-1导致肾损伤的自分泌/旁静脉机制的遗传模型,并提出内皮衍生的ET-1通过以旁静脉的方式启动肾小管细胞凋亡诱导肾损伤的工作假设 。

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