Cardiac responses to hypoxia and reoxygenation in Drosophila. New insights into evolutionarily conserved gene responses. Foeus on 'Cardiac responses to hypoxia and reoxygenation in Drosophila'

摘要

a simple heart tube propels hemolymph in the circulatory system of fruit fly Drosophila spp., and yet we find there is a great deal we can learn from these invertebrates regarding the regulation of cardiac contractility in the four-chambered hearts of mammals and how their myocardium responds to hypoxia. Indeed, in this issue of the American Journal of Physiology Regulatory, Integrated and Comparative Physiology, we learn that the cardiac responses of Drosophila to hypoxia depend greatly on time scale (10) and that Drosophila offer physiologists new insights into evolutionarily conserved gene responses.