Mitochondrial and Metabolic Drivers of Pulmonary Vascular Endothelial Dysfunction in Pulmonary Hypertension

摘要

The pulmonary vascular endothelium comprises a single layer of endothelial cells (ECs) on the inner layer of the vessel wall and controls a variety of vessel functions. These ECs participate in the regulation of vascular tone and barrier, leukocyte trafficking, blood coagulation, nutrient and electrolyte uptake, and neovascularization of hypoxic tissue [1].