Studies on spin-labelled peptide nucleic acid

摘要

Spin-labelled peptide nucleic acid TIO (PNAT10) was synthesized by solid-phase method with Boc strategy. The product was characterized by electron spin resonance (ESR) and time of flight MS (TOF MS) analysis, revealing a facile spin labelling of PNA by in situ sold-phase synthesis. The spin-labelled PNA product shows same hybridizing ability as that of native one and may be used in studying the cell membrane permeability of PNA by determination elf the ESR signals. [References: 18]