Genomic Surveillance Reveals Diversity of Multidrug-Resistant Organism Colonization and Infection: A Prospective Cohort Study in Liver Transplant Recipients

Macesic Nenad; Gomez-Simmonds Angela; Sullivan Sean B.; Giddins Marla J.; Ferguson Samantha A.; Korakavi Gautam; Leeds David; Park Sarah; Shim Kevin; Sowash Madeleine G.; Hofbauer Melanie; Finkel Ryan; Hu Yue; West Jared; Toussaint Nora C.; Greendyke William G.; Miko Benjamin A.; Pereira Marcus R.; Whittier Susan; Verna Elizabeth C.; Uhlemann Anne-Catrin

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Genomic Surveillance Reveals Diversity of Multidrug-Resistant Organism Colonization and Infection: A Prospective Cohort Study in Liver Transplant Recipients

机译：基因组监测揭示了多药物抗性殖民化和感染的多样性：肝移植受者的前瞻性队列研究

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Background. Multidrug-resistant organisms (MDROs) are an important cause of morbidity and mortality after solid organ transplantation. We aimed to characterize MDRO colonization dynamics and infection in liver transplant (LT) recipients through innovative use of active surveillance and whole-genome sequencing (WGS).

机译：背景。多药物抗性生物（MDROS）是固体器官移植后发病率和死亡率的重要原因。我们旨在通过创新使用活性监测和全基因组测序（WGS）来表征肝移植（LT）接受者的MDRO定植动力学和感染。

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来源
《Clinical infectious diseases》 |2018年第6期|共8页
作者
Macesic Nenad; Gomez-Simmonds Angela; Sullivan Sean B.; Giddins Marla J.; Ferguson Samantha A.; Korakavi Gautam; Leeds David; Park Sarah; Shim Kevin; Sowash Madeleine G.; Hofbauer Melanie; Finkel Ryan; Hu Yue; West Jared; Toussaint Nora C.; Greendyke William G.; Miko Benjamin A.; Pereira Marcus R.; Whittier Susan; Verna Elizabeth C.; Uhlemann Anne-Catrin;
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作者单位

Columbia Univ Med Ctr Div Infect Dis New York NY USA;

Columbia Univ Med Ctr Div Infect Dis New York NY USA;

Columbia Univ Med Ctr Div Infect Dis New York NY USA;

Columbia Univ Med Ctr Div Infect Dis New York NY USA;

Columbia Univ Med Ctr Div Infect Dis New York NY USA;

Columbia Univ Med Ctr Div Infect Dis New York NY USA;

Columbia Univ Med Ctr Div Infect Dis New York NY USA;

Columbia Univ Med Ctr Div Infect Dis New York NY USA;

Columbia Univ Med Ctr Div Infect Dis New York NY USA;

Columbia Univ Med Ctr Div Infect Dis New York NY USA;

Columbia Univ Med Ctr Div Infect Dis New York NY USA;

Columbia Univ Med Ctr Div Infect Dis New York NY USA;

Columbia Univ Med Ctr Div Infect Dis New York NY USA;

Columbia Univ Med Ctr Div Infect Dis New York NY USA;

New York Genome Ctr New York NY USA;

Columbia Univ Med Ctr Div Infect Dis New York NY USA;

Columbia Univ Med Ctr Div Infect Dis New York NY USA;

Columbia Univ Med Ctr Div Infect Dis New York NY USA;

Columbia Univ Med Ctr Dept Pathol &

Cell Biol Clin Microbiol Lab New York NY USA;

Columbia Univ Med Ctr Div Digest &

Liver Dis New York NY USA;

Columbia Univ Med Ctr Div Infect Dis New York NY USA;

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原文格式 PDF
正文语种 eng
中图分类传染病;
关键词
multidrug-resistant organism colonization; multidrug-resistant organism infection; carbapenem-resistant Enterobacteriaceae; whole-genome sequencing; liver transplantation;

机译：多药物的生物殖民化;多药物抗菌感染;耐肠道肠杆菌菌;全基因组测序;肝移植;

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专利

1. Genomic Surveillance Reveals Diversity of Multidrug-Resistant Organism Colonization and Infection: A Prospective Cohort Study in Liver Transplant Recipients [J] . Macesic Nenad, Gomez-Simmonds Angela, Sullivan Sean B., Clinical infectious diseases . 2018,第6期

机译：基因组监测揭示了多药物抗性殖民化和感染的多样性：肝移植受者的前瞻性队列研究
2. Vancomycin-Resistant Enterococcal Colonization and Infection in Liver Transplant Candidates and Recipients: A Prospective Surveillance Study [J] . Shelly A. McNeil, a, Preeti N. Malani, Clinical Infectious Diseases . 2006,第2期

机译：耐万古霉素的肠球菌定植和感染在肝移植候选对象中的应用：一项前瞻性监测研究。
3. Colonization and infection due to carbapenemase-producing Enterobacteriaceae in liver and lung transplant recipients and donor-derived transmission: a prospective cohort study conducted in Italy [J] . Errico G., Gagliotti C., Monaco M., Clinical microbiology and infection: European Society of Clinical Microbiology and Infectious Diseases . 2019,第2期

机译：肝脏和肺移植受者的肠蛋白酶肠杆菌肠杆菌和供体衍生传播引起的殖民化和感染：意大利进行了一项预期队列研究
4. In utero arsenic exposure and infant infections in a United States cohort: A prospective study [C] . Shohreh Farzan, Susan A. Korrick, Zhigang Li, Annual conference of the International Society of Exposure Science . 2014

机译：美国队列中子宫内砷暴露和婴儿感染的前瞻性研究
5. Correlates and Outcomes of Pre-Transplant Quantitative Interferon Mitogen Responses in Abdominal Transplant Recipients: A Single Center Retrospective Cohort Study [D] . Shimasaki, Teppei. 2018

机译：腹移植受体中移植前定量干扰素丝带丝糖尿剂反应的相关性和结果：单一中心回顾队列研究
6. Genomic Surveillance Reveals Diversity of Multidrug-Resistant Organism Colonization and Infection: A Prospective Cohort Study in Liver Transplant Recipients [O] . Nenad Macesic, Angela Gomez-Simmonds, Sean B Sullivan, -1

机译：基因组监测揭示了耐多药生物体定植和感染的多样性：肝移植受者的前瞻性队列研究。
7. Genomic Surveillance Reveals Diversity of Multidrug-Resistant Organism Colonization and Infection: A Prospective Cohort Study in Liver Transplant Recipients [O] . Nenad Macesic, Angela Gomez-Simmonds, Sean B Sullivan, 2018

机译：基因组监测揭示了多药物栓塞和感染的多样性：肝脏移植受者的前瞻性队列研究

Genomic Surveillance Reveals Diversity of Multidrug-Resistant Organism Colonization and Infection: A Prospective Cohort Study in Liver Transplant Recipients

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