Two studies on reversal of opioid-induced respiratory depression by BK-channel blocker GAL021 in human volunteers.

Margot Roozekrans; Rutger van der Schrier; Pieter Okkerse; Justin Hay; James F McLeod; Albert Dahan

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Two studies on reversal of opioid-induced respiratory depression by BK-channel blocker GAL021 in human volunteers.

机译：BK通道阻滞剂GAL021逆转人类志愿者对阿片类药物引起的呼吸抑制的两项研究。

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GAL021 produces respiratory stimulatory effects during opioid-induced respiratory depression with containment of opioid-analgesia and without any further increase of sedation. Further studies are needed to confirm these preliminary data.

机译：GAL021在阿片类药物引起的呼吸抑制过程中产生呼吸刺激作用，抑制了阿片类药物的镇痛作用，并且镇静作用没有任何进一步增加。需要进一步的研究以确认这些初步数据。

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《Anesthesiology》 |2014年第3期|共10页
作者
Margot Roozekrans; Rutger van der Schrier; Pieter Okkerse; Justin Hay; James F McLeod; Albert Dahan;
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正文语种 eng
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1. Two studies on reversal of opioid-induced respiratory depression by BK-channel blocker GAL021 in human volunteers. [J] . Margot Roozekrans, Rutger van der Schrier, Pieter Okkerse, Anesthesiology . 2014,第3期

机译：BK通道阻滞剂GAL021逆转人类志愿者对阿片类药物引起的呼吸抑制的两项研究。
2. Reversal of opioid-induced respiratory depression by BK-channel blocker GAL021: A pharmacokinetic-pharmacodynamic modeling study in healthy volunteers [J] . Roozekrans M., Olofsen E., van der Schrier R., Clinical Pharmacology and Therapeutics . 2015,第6期

机译：BK通道阻滞剂GAL021逆转阿片类药物引起的呼吸抑制：健康志愿者的药代动力学-药效学模拟研究
3. Reversal of opioid-induced respiratory depression by BK-channel blocker GAL021: A pharmacokinetic-pharmacodynamic modeling study in healthy volunteers [J] . Roozekrans M., Olofsen E., van der Schrier R., Clinical Pharmacology and Therapeutics . 2015,第6期

机译：BK沟道阻滞剂GAL021的阿片类药物呼吸抑郁症的逆转：健康志愿者的药代动力学 - 药物动力学建模研究
4. Pharmacokinetic study of liposome liposome-encapsulated and plain mepivacaine formulatio formulations injected ns intra intra-orally in human volunteers volunteers. [C] . Annual meeting exposition of the Controlled Release Society . 2009

机译：脂质体脂质体包封的药代动力学研究和普遍的MEPIVACAINE配方在人类志愿者志愿者中注射NS内部注射NS的NS内。
5. G-Protein Signaling Regulating Opioid-Induced Respiratory Rate Depression [D] . Danaf, Jamil. 2020

机译：G蛋白信号调节阿片类药物诱导的呼吸速率抑郁症
6. Opioid-induced respiratory depression: reversal by non-opioid drugs [O] . Rutger van der Schier, Margot Roozekrans, Monique van Velzen, 2014

机译：阿片类药物引起的呼吸抑制：非阿片类药物逆转
7. Two Studies on Reversal of Opioid-induced Respiratory Depression by BK-channel Blocker GAL021 in Human Volunteers [O] . Margot Roozekrans, Rutger van der Schrier, Pieter Okkerse, 2014

机译：BK频道阻滞剂Gal021在人志愿者中对阿片类药物呼吸抑郁症逆转的两项研究
8. Deposition of Ultrafine Aerosols in the Respiratory Tract of Human Volunteers. [R] . shanty,frank 1974

机译：人类志愿者呼吸道中超细气溶胶的沉积。

Two studies on reversal of opioid-induced respiratory depression by BK-channel blocker GAL021 in human volunteers.

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