An Efficient and Facile Access to Substituted 1E,3E-Dienylphosphonates via Horner-Wadsworth-Emmons Olefination of alpha,beta-Unsaturated Aldehydes with Tetraethyl Methylenebisphosphonate

摘要

An operationally simple and high-yielding synthetic method for 1E,3E-dienylphosphonates has been developed through the Horner-Wadsworth-Emmons olefination of alpha,beta-unsaturated aldehydes with tetraethyl methylenebisphosphonate, in heterogeneous medium, in the presence of solid potassium carbonate, in refluxing DMF.