Vascular thrombosis associated with aprotinin and deep hypothermic circulatory arrest: where are we in 2006?

摘要

To the Editor:-I read with great interest the recent report by Shore-Lesserson and Reich detailing diffuse venous thromboembolism in the setting of aprotinin and adult deep hypothermic circulatory arrest. To my knowledge, this is the first reported case of venous thrombosis associated with aprotinin and adult deep hypothermic circulatory arrest in the era of adequate heparinization, as defined by standard-of-care activated clotting time and heparin levels. This case report adds to the recent reports of arterial thrombosis (both pulmonary and systemic) associated with aprotirnn in adult cardiac surgery with or without deep hypothermic circulatory arrest.