机译:基于胍基的二价肽染色体抑制K-RAS戊基化和与C-RAF的关联
The Institute of Scientific Industrial Research Osaka University 8-1 Mihogaoka Ibaraki Osaka 567-0047 (Japan);
Academic Assembly Institute of Agriculture Shinshu University 8304 Minami-Minowa Kami-Ina Nagano 399-4598 (Japan);
Department of Pharmaceutical Science University of South Florida Tampa Florida 33612 (USA);
Ina Laboratory Medical &
Biological Laboratories CO. Ltd. Ina Nagano 396-0002 (Japan);
Ina Laboratory Medical &
Biological Laboratories CO. Ltd. Ina Nagano 396-0002 (Japan);
Institute for Chemical Research Kyoto University Gokasho Uji Kyoto 611-0011 (Japan);
Academic Assembly Institute of Agriculture Shinshu University 8304 Minami-Minowa Kami-Ina Nagano 399-4598 (Japan);
The Institute of Scientific Industrial Research Osaka University 8-1 Mihogaoka Ibaraki Osaka 567-0047 (Japan);
Department of Pharmaceutical Science University of South Florida Tampa Florida 33612 (USA);
Academic Assembly Institute of Agriculture Shinshu University 8304 Minami-Minowa Kami-Ina Nagano 399-4598 (Japan);
bivalent inhibitors; c-Raf; K-Ras; prenylation; protein-protein interactions;
机译:基于胍基的二价肽染色体抑制K-RAS戊基化和与C-RAF的关联
机译:拟肽修饰可改善二价法呢基转移酶抑制剂的细胞渗透
机译:c-Raf,而不是B-Raf,对于K-Ras癌基因驱动的非小细胞肺癌的发展至关重要。
机译:用于优化K-RAS G12C共价抑制剂的质谱
机译:K-Ras和B-Raf致癌基因通过ERK介导的结肠上皮细胞c-myc调节来抑制极性建立。
机译:法尼基转移酶介导的共价抑制剂的传递克服了替代的烯丙基化来错位K-Ras。
机译:法呢基转移酶和甲苯基酰基转移酶I抑制剂都是抑制致癌k-ras戊烯化的抑制剂,但单独每种单独都足以抑制裸鼠异种移植物中的人肿瘤生长