Large-scale synthesis of dihydrostreptomycin via hydrogenation of streptomycin in a membrane dispersion microreactor

摘要

Highlights?A novel method for the preparation of dihydrostreptomycin.?Conversion rate (99.5%) of streptomycin were reached in 3?min.?The difference between the microreactor and the traditional stirring tank was investigated.?The effect of the pH of the aqueous solution and other factors was investigated.AbstractIn this work, a membrane dispersion microreactor was applied for the hydrogenation of streptomycin (STR) to produce dihydrostreptomycin (DHS). The reductant was dispersed into the continuous phase containing STR, leading to a significant increase in the mass-transfer specific surface area, and the conversion rate of STR reached 99.81?wt% within 3?min. In contrast, in stirred tanks, the conversion rate of STR only reached 99.5% in 30?min. Moreover, the minimum amount of KBH4used in the membrane dispersion microreactor was about 35.71% lower than that in traditional tanks, when achieving the same conversion rate at about 99.5%.]]>