Biocompatibility of Tissue Engineering Constructions from Porous Polylactide Carriers Obtained by the Method of Selective Laser Sintering and Bone Marrow-Derived Multipotent Stromal Cells

摘要

We studied the biocompatibility of porous polylactide carrier matrices obtained by means of surface selective laser sintering. Carrier matrices had no cytotoxic activity, but maintained adhesion and proliferation of cells. Subcutaneous transplantation of tissue engineering constructions from these carriers and bone marrow-derived multipotent stromal cells did not cause the inflammatory response and pathological changes in rats. The conditions for organotypic regeneration were provided at the site of transplantation (high degree of blood supply and considerable amount of immature precursor cells).The development of tissue engineering constructs (TEC) from three-dimensional (3D) biodegradable matrices, which are resorbed in vivo with the repair of the damaged, is one of the main trends in modern tissue engineering. The matrices are prepared from various materials (ceramics, bioactive glass, etc.).