Endomorphin-1 attenuates A beta(42) induced impairment of novel object and object location recognition tasks in mice

摘要

A growing body of evidence suggests that the agglomeration of amyloid-beta (A beta) may be a trigger for Alzheimer's disease (AD). Central infusion of A beta 42 can lead to memory impairment in mice. Inhibiting the aggregation of A beta has been considered a therapeutic strategy for AD. Endomorphin-1 (EM-1), an endogenous agonist of mu-opioid receptors, has been shown to inhibit the aggregation of A beta in vitro. In the present study, we investigated whether EM-1 could alleviate the memory-impairing effects of A beta(42) in mice using novel object recognition (NOR) and object location recognition (OLR) tasks. We showed that co-administration of EM-1 was able to ameliorate A beta(42)-induced amnesia in the lateral ventricle and the hippocampus, and these effects could not be inhibited by naloxone, an antagonist of p-opioid receptors. Infusion of EM-1 or naloxone separately into the lateral ventricle had no influence on memory in the tasks. These results suggested that EM-1 might be effective as a drug for AD preventative treatment by inhibiting A beta aggregation directly as a molecular modifier. (C) 2015 Elsevier B.V. All rights reserved.