De(bar)coding aged hematopoiesis in primates

摘要

In this issue of Blood, Yu et al used genetic barcoding of hematopoietic stem and progenitor cells (HSPCs) to study the impact of age on the hematopoietic reconstitution in primates and observe delayed emergence of multilineage clones and skewed hematopoiesis compared with younger controls. This experimental model represents a significant advance to study aged hematopoiesis.(1)