Accelerating myelofibrosis through loss of Dnmt3a

摘要

In this issue of Blood, Jacquelin et al report that loss of DNA methyltransferase 3A (Dnmt3a) in hematopoietic cells expressing mutant Jak2V617F promotes progression from polycythemia vera to myelofibrosis leading to bone marrow failure and premature mortality.(1)