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首页> 外文期刊>Biochemical and Biophysical Research Communications >Low dose Emodin induces tumor senescence for boosting breast cancer chemotherapy via silencing NRARP
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Low dose Emodin induces tumor senescence for boosting breast cancer chemotherapy via silencing NRARP

机译:低剂量大蒜蛋白通过沉默的NRARP诱导肿瘤衰老,用于促进乳腺癌化疗促进乳腺癌化疗

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摘要

Purpose: The resistance to 5-FU often limits its clinical effectiveness on breast cancer treatment. Combination therapy thus is employed to overcome this treatment resistance. We here report a potent antitumor effect of Emodin at low dose on chemotherapy sensitivity of MCF-7 breast cancer cells.
机译:目的:对5-FU的抵抗力通常限制其对乳腺癌治疗的临床效果。 因此采用组合疗法来克服这种治疗抗性。 我们在这里报告了大黄素在低剂量上对MCF-7乳腺癌细胞化疗敏感性的有效抗肿瘤作用。

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  • 来源
  • 作者单位

    China Med Univ Affiliated Hosp 1 Canc Inst Lab 1 Shenyang 110001 Liaoning Peoples R China;

    China Med Univ Affiliated Hosp 1 Canc Inst Lab 1 Shenyang 110001 Liaoning Peoples R China;

    China Med Univ Affiliated Hosp 1 Canc Inst Lab 1 Shenyang 110001 Liaoning Peoples R China;

    China Med Univ Affiliated Hosp 1 Canc Inst Lab 1 Shenyang 110001 Liaoning Peoples R China;

    China Med Univ Affiliated Hosp 1 Canc Inst Lab 1 Shenyang 110001 Liaoning Peoples R China;

    Fudan Univ Obstet &

    Gynecol Hosp Dept Breast Surg 419 Fangxie Rd Shanghai 200011 Peoples R;

    China Med Univ Affiliated Hosp 1 Canc Inst Lab 1 Shenyang 110001 Liaoning Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 生物化学;
  • 关键词

    Emodin; Senescence; NRARP; 5-FU;

    机译:em Odin;senescence;NR ARP;5-F U;

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