Synthesis and cytotoxic activity of a new potent daunomycinone derivative.

Aligiannis N; Pouli N; Marakos P; Skaltsounis AL; Pratsinis H

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Synthesis and cytotoxic activity of a new potent daunomycinone derivative.

机译：新型高潮霉素衍生物的合成和细胞毒性活性。

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The preparation and cytotoxic activity of 4'-azido-3'-bromo-3'-deamino-4'-deoxydaunorubicin is described. The new compound was found to be less active in vitro than adriamycin against L1210 and the sensitive cell lines KB-3-1 and MES-SA, but retained interesting cytotoxicity against the adriamycin resistant subline KB-A1 and the multidrug resistant MES-SA/Dx5 subline.

机译：描述了4'- azido-3'-溴-3'-脱氧-4'-脱氧-4'-脱氧胺蛋白的制备和细胞毒性活性。发现新化合物比亚霉素对L1210和敏感细胞系KB-3-1和MES-SA的敏感性较低，而是对亚霉素抵抗宿司KB-A1和多药物抗性MES-SA的敏感细胞毒性保持有趣的细胞毒性/ DX5宿布。

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来源
《Bioorganic and Medicinal Chemistry Letters》 |2002年第24期|共3页
作者
Aligiannis N; Pouli N; Marakos P; Skaltsounis AL; Pratsinis H;
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作者单位

Division of Pharmacognosy Department of Pharmacy University of Athens Panepistimiopolis-Zografou 15771 Athens Greece;

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原文格式 PDF
正文语种 eng
中图分类药学;生物化学;
关键词
Synthesis; Adriamycin; daunomycinone; A1; 4'-deoxydaunomycin;

机译：合成;adriamycin;Daunomycinone;A1;4'-脱氧蛋白酶;

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1. Synthesis and cytotoxic activity of a new potent daunomycinone derivative. [J] . Aligiannis N, Pouli N, Marakos P, Bioorganic and Medicinal Chemistry Letters . 2002,第24期

机译：新型高潮霉素衍生物的合成和细胞毒性活性。
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Synthesis and cytotoxic activity of a new potent daunomycinone derivative.

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