Synthesis of novel C4-benzazole naphthalimide derivatives with potent anti-tumor properties against murine melanoma

Lu Yen-Ta; Chen Tien-Ling; Chang Kuo-Song; Chang Chia-Ming; Wei Tsai-Yin; Liu Jen-Wei; Hsiao Chih-Ang; Shih Tzenge-Lien

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Synthesis of novel C4-benzazole naphthalimide derivatives with potent anti-tumor properties against murine melanoma

机译：具有富有抗肿瘤性质的新型C4-苯并氮杂萘胺衍生物对鼠黑素瘤的新型C4-苯并咪唑衍生物

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Novel C4-benzazole naphthalimide derivatives were synthesized and tested in vitro and in vivo as anticancer drugs. Among these synthetic molecules, compounds 9 and 10 exhibited cytotoxicity against murine B16F10 melanoma cells. In addition, the above-mentioned compounds significantly suppressed lung tumor metastasis with no visible sign of toxicity. (C) 2016 Elsevier Ltd. All rights reserved.

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来源
《Bioorganic and medicinal chemistry》 |2017年第2期|共6页
作者
Lu Yen-Ta; Chen Tien-Ling; Chang Kuo-Song; Chang Chia-Ming; Wei Tsai-Yin; Liu Jen-Wei; Hsiao Chih-Ang; Shih Tzenge-Lien;
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作者单位

MacKay Mem Hosp Dept Med Chest Div Taipei 10449 Taiwan;

MacKay Mem Hosp Dept Internal Med Div Allergy Immunol &

Rheumatol Taipei 10449 Taiwan;

MacKay Mem Hosp Dept Emergency Med Taipei 10449 Taiwan;

MacKay Mem Hosp Dept Med Res New Taipei 25173 Taiwan;

MacKay Mem Hosp Dept Med Res New Taipei 25173 Taiwan;

Tamkang Univ Dept Chem New Taipei 25137 Taiwan;

Tamkang Univ Dept Chem New Taipei 25137 Taiwan;

Tamkang Univ Dept Chem New Taipei 25137 Taiwan;

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原文格式 PDF
正文语种 eng
中图分类药学;
关键词
Benzazole; B16F10 cells; Melanoma; MTS assay; Naphthalimide; Topoisomerase II;

机译：苯并唑;B16F10细胞;黑色素瘤;MTS测定;萘胺;Topoisomerase II;

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专利

1. Synthesis of novel C4-benzazole naphthalimide derivatives with potent anti-tumor properties against murine melanoma [J] . Lu Yen-Ta, Chen Tien-Ling, Chang Kuo-Song, Bioorganic and medicinal chemistry . 2017,第2期

机译：具有富有抗肿瘤性质的新型C4-苯并氮杂萘胺衍生物对鼠黑素瘤的新型C4-苯并咪唑衍生物
2. Synthesis of (S)-(+)-decursin and its analogues as potent inhibitors of melanin formation in B16 murine melanoma cells. [J] . Lee K, Lee JH, Boovanahalli SK, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2010,第12期

机译：（S）-（+）-递精蛋白及其类似物的合成作为B16鼠黑色素瘤细胞中黑色素形成的有效抑制剂。
3. Synthesis, DNA Binding, and Anticancer Properties of Bis-Naphthalimide Derivatives with Lysine-Modified Polyamine Linkers [J] . Yu Huang, Chun-Xia Wu, Yu Song, Molecules . 2018,第2期

机译：赖氨酸修饰的多胺接头的双萘二甲酰亚胺衍生物的合成，DNA结合和抗癌性能
4. The Synthesis and Electroluminescence Properties of 4-Benzofuranyl-1,8-Naphthalimide Derivatives [C] . YANG Jian-Xin, WANG Xiang-Hui International Conference on Chemical Engineering and Advanced Materials . 2012

机译：4-苯并呋喃基-1,8-萘酰亚胺衍生物的合成与电致发光性能
5. Synthesis and Biological Evaluation of Novel Resveratrol and Combretastatin A4 Derivatives as Potent Anti-Cancer Agents. [D] . Madadi, Nikhil Reddy. 2014

机译：新型白藜芦醇和Combretastatin A4衍生物作为强效抗癌药的合成及生物学评价。
6. Synthesis DNA Binding and Anticancer Properties of Bis-Naphthalimide Derivatives with Lysine-Modified Polyamine Linkers [O] . Yu Huang, Chun-Xia Wu, Yu Song, 2018

机译：赖氨酸修饰的多胺接头的双萘二甲酰亚胺衍生物的合成DNA结合和抗癌性能
7. Synthesis and Anti-tumor Effects of Naphthalimide Derivatives Targeted in Cell Nucleus [O] . Ruixue Rong, Jimin Li, Yaowen Li, 2021

机译：亚硫代亚胺衍生物在细胞核中的合成与抗肿瘤作用

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Synthesis of novel C4-benzazole naphthalimide derivatives with potent anti-tumor properties against murine melanoma

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