I would like to comment on the elegant study by Stahl et al. [1] that describes a novel tool for estimating blood loss [1].In the absence of a gold standard method, the authors made detailed efforts to quantify the mass of haemoglobin (HbMass) lost during 100 radical prostatectomy operations. A 'measured' blood loss volume was calculated from the HbMass and used in the derivation cohort (n = 50) to identify statistically significant clinical variables. This generated a prediction formula of blood loss for three peri-operative time points (the 'tool'). Agreement between predicted and measured was then assessed in the validation cohort (n = 50).
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