Membrane lipids in patients with chronic bronchitis concurrent with urolithiasis in the phase of clinical remission

摘要

The composition of erythrocytic lipids was studied in patients with chronic nonobstructive bronchitis in the phase of clinical remission concurrent with urolithiasis. There was a significant increase in the proportion of phosphatidylserine with the decreased levels of sphingomyelin and phosphatidylcholine, a reduction in the relative quantity of fatty acids of iso- and anteisometric structure, an impairment in the relations between fatty acids that are precursors of the synthesis of eicosanoids of different series, as well as a decrease in the total unsaturation of erythrocytic lipids. The impairments found in the composition of erythrocytic lipids are markers of membrane destruction and they may serve as diagnostic criteria for concomitant pulmonary and renal lesions.