口腔癌患者の周術期における尿中トリプシンインヒビター(UTI)排泄量の変動とその臨床的意義

摘要

This study was designed to investigate the potential clinical usefulness of urinary trypsin inhibitor (UTI) in monitoring and predicting the postoperative course of patients undergoing surgery under general anesthesia.Fifeen patients with oral cavity cancer were enrolled in this study. Urine samples were collected before and after surgery (day 1 to day 7),and were stored at -80deg until the assay,which was conducted by one-step sandwich ELISA methods.There were no circadian variations in UTI levels, and the normal reference range was 30.0 U/mg Cr.There were significant correlations between UTI levels and various parameters (WBC,AST,ALP,LAP and CRP).UTI levels reached maximum values at 3 days after surgery,and decreased to the baseline by 7 days after surgery.These results suggested that UTI levels were increased in patients who were under surgical stress and were significantly correlated with various parameters.Therefore, determination of UTI levels was confirmed to be useful as a simple and noninvasive test for monitoring the postoperative course of patients undergoing surgery under general anesthesia.