An unwelcome guest: Aspergillus colonization in lung transplantation and its association with bronchiolitis obliterans syndrome.

摘要

Despite the short-term success of lung transplantation, long-term outcomes remain among the worst of all routinely transplanted solid organs. The lung, perhaps because of direct environmental interactions and innate host defenses, appears uniquely vulnerable to alloimmune injury despite modern immunosuppression. Over 50% of lung transplant recipients experience acute rejection within the first year (1). Furthermore, a majority of patients develop bronchiolitis obliterans syndrome (BOS), a condition of progressive allograft dysfunction, within 5 years after transplant (1).