Pd-catalyzed coupling reaction of 6-hydroxy-2-(prop-2-yn-l-ylsulfanyl)pyrimidin-4(1H)-one with aryl iodides: efficient syntheses of new 3-benzylthiazolo [3,2-я] pyrimidinones

摘要

An efficient synthetic protocol was developed for the preparation of 3-benzyl-7(5)-hydroxy-5(7)H-[l,3]thiazolo[3,2-a]pyrimidin-5(7)-ones from 6-hydroxy-2-(prop-2-yn-1-ylsulfanyl)pyrimidin-4(1H)-one and aryl iodides in the presence of Pd-Cu complex catalyst. This one-pot process provides a simple and direct method for the synthesis of new thiazolo[3,2-u]pyrimidinones in good to high yields.