Re: 'Long-term use of beta-carotene, retinol, lycopene, and lutein supplements and lung cancer risk: results from the VITamins and Lifestyle (VITAL) Study'.

摘要

In their recent article, Satia et al. (1) used data from the VITamins And Lifestyle (VITAL) Study to draw some conclusions about an association between intake of dietary supplements and lung cancer risk. A previous VITAL Study publication concluded that multivitamin use does not increase lung cancer risk (2). The current study focused on long-term use of individual supplements at high doses. The participants using individual lutein supplements were categorized as noncancer cases (n = 1,606) and lung cancer cases in = 20). Relatively infrequent lutein supplement use by lung cancer cases made it impossible to divide the group with regard to dosage or duration of use. Satia et al. concluded that long-term use of high doses of individual P-carotene, retinol, and lutein supplements may be harmful in terms of lung cancer risk.