Chromatographic QSAR of 3-[omega-(4-Arylpiperazin-1-yl) alkyl] methylpyri-mido-[5,4-c] quinolin-4(3H)-ones for the 5-HT1A Receptor Characterization

摘要

Background: Quantitative structure-activity relationship studies of long chain arylpiperazines demonstrated that 5-HT1A affinity is influenced by the nature of the aryl group at N-1 of the piperazine ring and the length of the alkyl chain at N-4 position linked to terminal amide or imide part, but still the function of terminal amide/imide moieties is less clear.