EFFECT OF DAIDZEIN AND GENISTEIN ON SERUM GLUCOSE, LIPID PROFILE AND PAROXONASE ACTIVITY IN DIABETIC RATS

摘要

Evidence is emerging that soybean phyto estrogens play a beneficial role in diabetes. This study was conducted to evaluate the effect ofdaidzein andgenstein as most important isoflavones in soybean on glucose, lipid profile and antioxidant enzyme activities in diabetic rats. Sixty male Sprague-Dawley rats were divided into six equal groups. Experiments were performed for 21 days. The rats of Group A as healthy control and group B as diabetic control were fed laboratory standard diet. The rats of Groups C, D and E were fed standard laboratory diet plus 600 mgl kg daidzein, 600 mg/kg genstein, and 600 mglkg daidzein and genstein 50/50 respectively. Diabetes in groups B, C, D, and E was induced by a single injection of 60 'mgl kg body weight streptozotosin (STZ). Blood biochemical parameters such as serum glucose, T-Cholesterol, triglyceride (TG), LDL, HDL and Paraxonase activity were measured Daidzein and genistein showed a significant positive effects in ameliorating lipid profile in treatment groups. Administration of daidzein and genistein to the STZ-induced rats significantly increased paraxonase activity, our results indicate that supplementation diabetic rats with isoflavones was accompanied by an improvement in some indices of diabetes mellitus.