ミズクラゲのストロビレ一シヨンを制御する物質の探索

摘要

The life cycle of the moon jellyfish alternates between an asexual polyp stage and a sexual medusa (jellyfish) stage. Transition from polyp to medusa, called strobilation, can be artificially induced by dropping the water temperature. We screened a chemical library and commercially available compounds for substances to regulate strobilation and found the following bioactive compounds.(1)Indomethacin induced strobilation without lowering the temperature. (2) Acivicin (AT-125), an inhibitor of gamma-glutamyl transpeptidase, was a reversible inhibitor of strobilation. Notably, acivicin completely interrupted indomethacin- induced strobilation. (3) The lysosomal acidification inhibitors, chloroquine and bafilomycin A1,disturbed medusa morphogenesis of the disc at the oral end.