Catalytic Desymmetrization of meso-Aziridines with Benzofuran-2(3H)-Ones Employing a Simple In Situ-Generated Magnesium Catalyst

摘要

The first example of catalytic desymmetrization of meso-aziridines with benzofuran-2(3H) -ones is realized by employing a magnesium catalyst utilizing BINOL as a simple and commercially available chiral ligand. Both of the enantiomers of the ring-opening product could be easily accessed by employing (R)- or (S)-BINOL as chiral ligand, respectively. A variety of enantioenriched 3,3disubstituted benzofuran-2(3H)-ones containing multiple linear continuous stereocenters were obtained with moderate to good yields, diastereo- and enantioselectivities.