JSNP Excellent Presentation Award for CINP201b: Nicotine Evokes Convulsive Seizures by Activating Amygdala Neurons Partly Through a7 nACh Receptors

摘要

Nicotine acetylcholine (nACh) receptors are implicated in induction of convulsive seizures both in nicotine intoxication (Singer and Janz, 1990) and human epileptic disorders (e.g.,juvenile myoclonic epilepsy [JME]) (Liao et al,2011).However, the exact mechanisms underlying nicotinic seizures remain unknown. In the present study, therefore, we performed behavioral and Fos-immimohistochemistry studies using rodents in order to clarify the mechanisms of nicotine-induced seizures.