Quantitative analysis of indocyanine green angiography in multifocal posterior pigment epitheliopathy and its related diseases

摘要

PURPOSE: To clarify the indocyanine green(ICG) angiographic features in multifocal posterior pigment epitheliopathy(MPPE), we measured the maximum diameter of the choroidal vein and mean fluorescence intensity within the vascular arcade. METHODS: ICG angiography was performed in 40 eyes of 20 patients with MPPE and 10 age-matched normal controls, and quantified by IMAGEnet. RESULTS: The mean maximum choroidal venous diameter was 544 +/- 162(mean +/- standard deviation) microns in eyes with MPPE and 278 +/- 55 microns in healthy age-matched control eyes. The mean fluorescence intensity was 106.9 +/- 52.5 and 86.5 +/- 32.5, respectively. Both the mean maximum choroidal venous diameter and the mean fluorescence intensity showed statistical difference between the two groups. In contrast, there was no statistically significant difference between the eyes with serous retinal detachment and without detachment in the MPPE group. CONCLUSIONS: These results show that choroidal venous dilation and choroidal hyperfluorescence in MPPE are clearly distinguished from choroidal aging changes. Additionally, these pathological angiographic changes seemingly do not delineate the activity of MPPE, but demonstrate the background factor of the pathogenesis of MPPE.