Drs. Damaraju, Olson, and Canuso Reply

摘要

We appreciate the insightful comments made by Drs. Potkin and Siu in their reference to our article. As the editorial accompanying our article observed, the proportion of missing data in our study was small (<20%). The likelihood-based mixed-model repeated-measures analysis is generally robust to departures from the missing at random assumption when the sample size is large and the number of dropouts is small (1). In our study, results were consistent between the last observation carried forward and mixed-model repeated-measures analyses of the primary efficacy endpoint (day 14) based on the intent-to-treat data set. The mixed-model repeated-measures analyses utilized PANSS score data obtained at all visits, including the dropout visit.