Bilateral pallidal necrosis and cardiac toxicity in a patient with venlafaxine and bupropion overdose

摘要

The new generation of antidepressants is generaly thought to be safer than traditional antidepressants. Although combining antidepressants is recommended for the treatment of refractory depression, the toxicity of drug overdose from more than one antidepressant is seldom addressed. A 30-year-old woman was sent to the emergency department 1 hour after ingesting veniafaxine and bupropion in a suicide attempt. The exact dose was uncertain, but according to the metabolites of veniafaxine, bupropion, and benzodiazepine found in her urine, it is probable that she consumed a 1-month prescription of 150 mg veniafaxine, 300 mg bupropion, and 3 mg lorazepam that was prescribed 3 days earlier.